Bioactive Small Molecules
Cayman Chemical ANTIBODY GSK180736A 50mg
A ROCK1 and GRK2 inhibitor (IC50s = 14 and 0.77 µM, respectively); selective for GRK2 over GRK1, GRK5, and PKA (IC50 = >100 µM for all); selective for ROCK1 over RSK1 and p20S6K (IC50s = 3,100 and 2,850 nM, respectively); increases maximum contractility in isolated mouse cardiomyocytes at 1 µM
Meso Scale Discovery Akt Signaling WCL
The Meso Scale Discovery Akt Signaling Whole Cell Lysate Kit (K15115D) is designed to monitor Akt phosphorylation and activation in cells The kit includes a 96-well plate coated with capture antibodies for total and phosphorylated Akt (Ser473 and Thr308) It also includes detection antibodies and buffers needed to perform an ELISA-based assay to measure Akt phosphorylation The kit allows for high-throughput analysis of Akt signaling with as little as 2 ug of cell lysate per well Results are quantified on the MSD instrument platform and data is reported as electrochemiluminescence signal This kit enables robust and reproducible analysis of Akt activation and phosphorylation
Medchemexpress LLC Blu2864 | 2810747-89-6 | 99.5% | 452.43 | 100 MG
BLU2864 is an orally active, highly selective, ATP-competitive PRKACA inhibitor with an IC50 of 0.3 nM for PRKACA. It exhibits anti-tumor activity and can be utilized in cancer and polycystic kidney disease research.
- Inhibits forskolin-induced in vitro cystogenesis
- Suppresses renal basal and total PKA activities
- Leads to higher urine outputs and lower kidney weights
- Reduces FLC tumor growth
Cayman Chemical ANTIBODY ML-351 25mg
An inhibitor of human reticulocyte 15-LO-1 (IC50 = 200 nM) with >250-fold selectivity over the related enzymes 5-LO, platelet 12-LO, 15-LO-2, ovine COX-1, and human COX-2; protects against oxidative glutamate toxicity in mouse neuronal HT-22 cells and significantly reduces infarct size in an in vivo mouse model for ischemic stroke
Medchemexpress LLC Benzeneacetic acid cyclopentyl ester (CHR-2845) | 914382-60-8 | 99.7% | 495.61 g/mol | C28H37N3O5 | 1 ML
Tefinostat is a monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor prodrug used in preclinical research. It is converted intracellularly to the active acid metabolite and is supplied in research-ready formats for biochemical and cellular studies.
- Monocyte/macrophage-targeted HDAC inhibition suitable for immuno-oncology research.
- Prodrug that is cleaved intracellularly to the active acid metabolite.
- Available as a 10 mM solution in DMSO or as solid material for flexibility in use.
- High purity for reproducible experimental results.
- Supplied with a certificate of analysis for batch-specific quality data.
Medchemexpress LLC Phospho-p38 alpha/MAPK14 (Thr180+Tyr182) Antibody | 10 UL
Phospho-p38 alpha/MAPK14 (Thr180+Tyr182) Antibody is a rabbit-derived, non-conjugated IgG polyclonal antibody specifically targeting phosphorylated p38 alpha/MAPK14. This antibody is developed for research use only and is suitable for various immunological assays. It comes as an affinity-purified liquid formulation with a concentration of 1 mg/mL.
- Rabbit-derived IgG polyclonal antibody
- Targets specifically phosphorylated p38 alpha/MAPK14 (Thr180+Tyr182)
- Affinity purified for high specificity
- Suitable for multiple applications including Western Blot, IHC-P, FC, ICC/IF, and ELISA
- Reacts with human and mouse samples
- Stable for 1 year when stored at -20°C
Cayman Chemical ANTIBODY BAY-299 25mg
A potent and selective BRD1 inhibitor (IC50 = 6 nM); also inhibits the second bromodomain of TAF1 (IC50 = 13 nM); >30-fold selective over BRPF1, BRPF3, BRD9, and ATAD2; >300-fold selective over BRD4
Cayman Chemical ANTIBODY HY-17542 10mg
A SARS-CoV PLpro inhibitor (IC50 = 2.6 µM); increases the viability of SARS-CoV-infected Vero E6 cells (EC50 = 13.1 µM)
Medchemexpress LLC Ezh2-in-13 | 1403255-41-3 | 99.7% | 571.75 | 1 ML
EZH2-IN-13 is a potent EZH2 inhibitor, referenced as compound 73 in patent WO2017139404. It can be used for studying cancers or precancerous lesions associated with EZH2 activity. Identified uses include laboratory chemicals and the manufacture of substances.
- Potent EZH2 inhibitor
- For research use only
- Available in solid form and in solution (10 mM in DMSO)
- Intended for research use by experienced personnel in appropriately equipped and authorized facilities
- Not fully validated for medical applications
Medchemexpress LLC Guvacoline hydrobrom 1mg | 17210-51-4 | 1 MG
Guvacoline hydrobromide is the hydrobromide salt of guvacoline, a pyridine alkaloid that functions as a weak full agonist at atrial and ileal muscarinic acetylcholine receptors (mAChR). Supplied as a solid research chemical, it is intended for use in receptor pharmacology, in vitro assays, and compound characterization.
- Hydrobromide salt form suitable for in vitro studies
- Solid form with specified purity for reproducible results
- Acts as a muscarinic receptor agonist for pharmacological evaluation
- Stable under recommended sealed storage conditions to preserve integrity
- Offered in small quantities tailored to laboratory research needs
Medchemexpress LLC (-)-G-Lactone | 43119-28-4 | ≥98.0% | 124.14 | 500 MG
(-)-G-Lactone is a synthetic intermediate useful for prostaglandins synthesis. It is for research use only and not sold to patients.
- Appears as a solid
- Color is off-white to light yellow
- Store at room temperature for 3 years
- Store in solvent at -80°C for 2 years or -20°C for 1 year
Medchemexpress LLC Peroxiredoxin 1 Antibody (YA692) | 10 UL
This Peroxiredoxin 1 Antibody (YA692) is a mouse-derived antibody exhibiting reactivity with human, mouse, and rat samples. It has a molecular weight of 22 kDa and is supplied at a concentration of 1.72 mg/mL. This antibody is suitable for various applications including Western Blot (WB), Immunohistochemistry (frozen and paraffin-embedded sections), and Immunocytochemistry/Immunofluorescence (ICC/IF).
- Host: Mouse
- Reactivity with human, mouse, and rat samples
- Predicted and observed molecular weight: 22 kDa
- Concentration: 1.72 mg/mL
- Validated for Western Blot (WB), IHC-F, IHC-P, and ICC/IF applications
- Formulated in 1*PBS (pH 7.3), 50% glycerol, and 0.5% BSA
- Contains 0.02% sodium azide as a preservative
- Stable for 1 year when stored at -20°C
- Avoid repeated freeze/thaw cycles to maintain integrity
Medchemexpress LLC HY-111540 10mg Medchemexpress, IDO1-IN-5 CAS:2166616-75-5 Purity:>98%
Medchemexpress, HY-111540 10mg IDO1-IN-5 CAS:2166616-75-5 IDO1-IN-5 is a potent, selective and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical LeucomycIn A4 5mg
A macrolide antibiotic; active against a variety of bacteria, including S. aureus, B. subtilis, C. diphtheriae, N. gonorrhoeae, and H. influenzae (MICs = 0.15, 1.25, 0.15, 0.6, and 0.15 UG/ml, respectively)